Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada
نویسندگان
چکیده
منابع مشابه
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic...
متن کاملmerkel cell polyomavirus infection in a patient with merkel cell carcinoma: a case report
conclusions the findings of this study are consistent with the hypothesis that local, systemic, or tumor-induced immunosuppression may allow the mcpyv to initiate skin aggressive cancer. it is necessary to maintain regular check over patients taking immunosuppressive medications for mcpyv infection. since there is not any information about detection and molecular biology analysis of mcpyv among...
متن کاملMerkel cell polyomavirus infection in HIV-positive men.
OBJECTIVE To evaluate Merkel cell polyomavirus (MCPyV) DNA prevalence and load among men with human immunodeficiency virus (HIV) (hereafter referred to as HIV-positive men) and among healthy male control subjects. DESIGN Prospective study from February 4, 2009, through April 24, 2010. SETTING Dermatology department of a university hospital. PATIENTS A total of 449 male adults were prospec...
متن کاملAsymptomatic Primary Merkel Cell Polyomavirus Infection among Adults
Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. We examined data for 564 gay/bisexual male participants >18 years of age in the Multicenter AIDS Cohort Study in Pittsburgh, Pennsylvania, USA, and found that 447 (79.3%) were MCV-antibody positive at initial enrollment. Of the 117 MCV-seronegative men, 31 subsequently seroconverted over a 4...
متن کاملMerkel cell polyomavirus infection and host defence in patients with Merkel cell carcinoma
Background and purpose: Merkel cell carcinoma (MCC) is a rare and often aggressive skin cancer that usually arises in elderly individuals. MCC is frequently associated with ultraviolet radiation exposure and immunosuppressive conditions. The majority of MCCs harbor Merkel cell polyomavirus (MCPyV), a newly discovered human cancer virus. Several studies have indicated its importance in MCC tumor...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2010
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1611.100628